Welcome to the Hill Lab
The Hill lab is part of the Department of Medical Oncology and Division of Molecular and Cellular Oncology at Dana-Farber Cancer Institute.
The mission of the Hill Lab is to develop a deep mechanistic understanding of breast, ovarian, and endometrial cancer development and tumor biology which we will harness to make these cancers more manageable diseases for all patients through the development of effective methods of detection, prevention, and treatment.
In pursuit of this mission, the Hill lab focuses on understanding the role of the BRCA1 tumor suppressor and cell cycle checkpoints in basic molecular and cellular biology and in breast, ovarian, and endometrial carcinogenesis and tumor biology.
We utilize molecular/cellular biology and fluorescence microscopy techniques in breast, ovarian, and endometrial cancer cell lines and mouse models.
The mission of the Hill Lab is to develop a deep mechanistic understanding of breast, ovarian, and endometrial cancer development and tumor biology which we will harness to make these cancers more manageable diseases for all patients through the development of effective methods of detection, prevention, and treatment.
In pursuit of this mission, the Hill lab focuses on understanding the role of the BRCA1 tumor suppressor and cell cycle checkpoints in basic molecular and cellular biology and in breast, ovarian, and endometrial carcinogenesis and tumor biology.
We utilize molecular/cellular biology and fluorescence microscopy techniques in breast, ovarian, and endometrial cancer cell lines and mouse models.
News and Highlights
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Harvard Biological and Biomedical Sciences (BBS) Program Rotation Students are welcome! Email Dr. Hill directly about rotation opportunities ([email protected])
We are looking for a postdoctoral fellow to join the Hill lab! If interested, please send an email to [email protected] with a cover letter describing your past research, your future goals, and why you would like to join the Hill lab. Please include a CV and contact information for three references who can speak to your scientific achievements. A strong work ethic and training in molecular and cellular biology are needed. This is a wet bench lab, and work will be onsite 100% of the time. We are looking for postdocs who have published first author papers and are motivated to acquire fellowships to support your work at Harvard & DFCI. Follow us on Twitter @SarahJHill6 |
-5/7/2025-Dr. Hill speaks at BRCA 2025 conference.
-4/30/25-NEW PAPER! Congrats Dr. Yang! -10/7/24-Dr. Shuai Zhao joins the lab as a post-doctoral fellow. Welcome Dr. Zhao! -9/16/24-Dr. Justin Blaize joins the lab as a post-doctoral fellow. Welcome Dr. Blaize! -4/2/24-NEW PAPER! Check out this exciting collaboration with Rueda lab at MGH on a new ovarian cancer therapy! Congrats to Bo and Linah! -3/25/24-NEW PAPER! Check out our latest work on atypical uterine leiomyomata! -3/4/24-NEW PAPER! Check out this exciting collaboration with Rueda Lab at MGH on Uterine Serous Cancer. Congrats to Bo and Yusuke! -1/29/24-NEW PAPER! Check out our latest work describing how a new BRCA1 protein complex called ORFIUS regulates replication origins -12/9/23-NEW PAPER! Check out our review on endometrial cancer risk in BRCA1/2 germline carriers -11/17/23-Dr. Hill presents on ovarian cancer co-culture systems at the Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences Seminar Series -10/11/23-Congratulations to Dr. Yang on receiving a Friends of Dana-Farber grant to study DNA replication in ovarian cancer! -11/3/23-Dr. Hill speaking on BRCA-like women's cancers at Genome Instability- Discovery to Personalized Medicine conference -7/24/23-Dr. Hill speaks on BRCA1 biology across women's cancer at Hillman Cancer Center -6/28/23-Dr. Hill receives Susan G. Komen Career Catalyst Research Grant to study DNA damage beyond PARP in triple negative breast cancer -3/30/23-Dr. Hill speaks on ovarian cancer at Magee-Womens Research Institute -3/8/23-Dr. Hill speaks on ovarian cancer at Rutgers Cancer Institute New Jersey -2/16/23-Dr. Hill receives ASCI Young Physician-Scientist Award -12/1/22-Congratulations to Saie on becoming a Helen Gurley Brown Fellow for her work on endometrial cancer -05/09/22-Dr. Hill Speaks at Koch Institute Oncology Seminar Series -05/06/22-Dr. Hill Receives DOD PRCRP Impact Award to work on TP53 mutant endometrial cancer -04/11/22-Dr. Hill to present on Advances in Ovarian Cancer at the AACR Annual Meeting as a NextGen Star Award winner -03/20/22-Dr. Hill to present on women's cancer organoid modeling at the AACR companion USCAP meeting -1-11-22-Congratulations to Zelei for winning an OCRA Ann and Sol Schreiber Mentored Investigator Award -9/23/21-Dr. Hill Present at Dana-Farber's Seminars in Oncology -9/8/21 Dr. Zelei Yang joins the lab as a post-doctoral fellow. Welcome Dr. Yang! -5/3/21 New Paper! Katherine Lynch in Cancers "Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1–AKT–p53 Interactions" -Dr. Hill wins the Cancer Research Early Career Award for her paper Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer -AACR recognizes Hill Lab's manuscript on novel mechanism for enhancing immune therapy efficacy in ovarian cancer -Dr. Hill featured in Tina's Wish Thank You video -Hill lab manuscript using organoid co-cultures entitled "Enhanced efficacy of simultaneous PD-1 and PD-L1 immune checkpoint blockade in high grade serous ovarian cancer" available online. -10/14/20-Dr. Hill Presents for the Society for Functional Precision Medicine 10/6/2020-Dr. Hill receives NIH Director's Early Independence Award (DP5) -10/6/20-Dr. Hill lectures in HST030 at Harvard Medical School -10/1/2020-Dr. Hill promoted to Assistant Professor of Pathology at Harvard Medical School -7/14/20-Dr. Hill presents at the Englander Institute for Precision Medicine -07/2020-Ms. Katherine Lynch joins the lab as an RA. Welcome Katherine! |
